There is quite a brilliant debate between Thuderf00t and Eric Hovind on YT (quite lengthy, but well worth it)
I think Thunderf0ot should have taken it one step further backwards, and said that mathematics is the thing underpinning the fundamental basic assumption that reality exists. If you can prove something mathematically, it can with certainty be said to exists. Because.. how can you disprove Mathematics? You cannot quantify "Mathematics", there is no way of measuring it, and to measure you have to have Philosophy. You would have to use Physics to quantify and disprove Mathematics, and you can't have physics without mathematics or forms without Philosophy - so you are kinda screwed there.
However, can Mathematics be disprooved? Can we construct a better tool to measure reality? Well.. I'm not 100% certain, but I'm quite sure we cannot. Though I do think Statistics is the best evidence for Mathematics, and the best evidence for Statistics is Physics and Biology. However, if somehow mankind found a better way to understand the fundamental basic assumptions about reality than math it would be kinda cool. Theology surely isn't a better way to understand it, it explains exactly nothing, and it will continue to do so. The good thing about Science is that it proves things, such as Theology, which are exactly wrong. Something cannot be proved true, can only prove something false.