Evidence of evolutionary selection found in 544 genes


(PhysOrg.com) -- By comparing the genomes of humans and five other mammals, Cornell researchers have identified 544 genes that have been shaped by positive selection over millions of years of evolution.
"To our knowledge this is the largest and most comprehensive analysis of positive selection to date," write the researchers in the Aug. 1 issue of the journal PLoS Genetics, reporting on research mainly funded by the National Science Foundation. Natural selection (favorable traits becoming more common over successive generations) that tends to favor new forms of genes is known as positive selection.

Previously, the Cornell group compared the genomes of humans, chimpanzees and the Rhesus macaque. By extending the analysis to mice, rats and dogs, the researchers were able to find "stronger signals" of change by going back up to 80 million years on the evolutionary tree. Other studies have found signatures of positive selection using population genetics methods -- comparing genomes across many members of the same species -- but those focus on changes over just the last tens of thousands of years.

The researchers -- including Adam Siepel, Cornell assistant professor, and Carlos Bustamante, Cornell associate professor, both of biological statistics and computational biology; and Cornell postdoctoral researchers Carolin Kosiol and Tomas Vinar -- used a high-performance computer cluster at the Cornell Center for Advanced Computing to study 16,500 human genes that are also found, with some differences, in at least two of the other five species.

Over time, random changes can occur in the genetic code that replace one of the amino acids in a protein with another. Sometimes these changes have no effect on the function of the protein. But if the change alters the function of the protein and the change is beneficial -- if, for example, it protects against a disease that is common in a certain time and place -- individuals with the new version of the gene will be more likely to survive than others, and the new version will gradually replace the old one in an evolving population.

Siepel's group used the unimportant changes as a sort of clock to show how much change would be expected over evolutionary time. If a gene showed significantly more change than expected by random chance it was predicted to be under positive selection.

Many of the positively selected genes found in rodents involved immunity and defense, including defense against bacteria and viruses, suggesting an evolutionary "arms race" with pathogens. Responses to wounding and inflammation were also common.

The largest group of positively selected genes in primates involved sensory inputs -- including perceptions of taste, color and pain. "The conventional wisdom is that we should see major changes in the brain-related genes," Siepel noted. "We didn't find a signal for that, but did find inputs to the central nervous system." Perhaps, the researchers speculated, changes in sensory input drove changes in the brain.

The study supports the idea that positive selection is important in evolution, Siepel said. Theorists have argued over the relative importance of positive selection versus "neutral drift," where random changes simply happen with no positive or negative result. He noted that positive selection was found mainly in genes that are not expressed in as many tissues as others. "Genes with more specialized purposes may have more freedom for adaptation," he explained.

The researchers also found evidence that many changes seem to have occurred in spurts over short periods of time. For example, they found genes that were not under selection in lower mammals, then came under selection in primates, then were lost in humans. Whether evolution has been continuous or episodic has also been a subject of much debate among biologists.

Provided by Cornell University

Views: 5

Comment by Morgan Matthew on September 17, 2008 at 12:28pm
The debate is finally over, the church has officially apologized to Darwin for not understanding his theory, and we have evidence for positive selection backing up the theory of evolution most definitively. I'm sure all rational religious people will now finally admit that they were simply misinformed and will gladly accept this proof as irrefutable... right? heh I doubt it :P
Comment by StarDeath on September 17, 2008 at 12:55pm
Dear intolerant, arrogant, ignorant, pathetic Christian nutbar,

Did you give your kid vaccinations? Thank the study of evolution for it, cause prayer sure as hell didn't kill polio...

Evolution is a real process whether your lying ass likes it or not. No matter how many lies, mistruths, and non-sequiturs you spout here. Evolution is a real process even if you're offended by it. Evolution is a real process even if you feel it contradicts your religion. The fact of the matter is that evolution is a real process, a proven process - a real part of our objective universe.

So, if Truth is something that matters to you, then you cannot 'disbelieve' in evolution or preach against it. Then again, if you don't care about lying, deceiving, and misleading others, then you can obviously do and say whatever you want - regardless of whether it's true or not.

Evolution is biology, the evidence is there for it. The evidence for creation? All you can come up with is a 'Invisible Sky Daddy"?! Not science, sorry.

And if you ignorant, arrogant, thick headed assholes don't like evolution then publish evidence that challenges it. No more debates filled with fancy symantics, just back up your statments with actual science.

Feel free to believe in whatever brand of bullsh1t you want, but when those beliefs begin to turn into laws and campaign platforms, you've overstepped the boundry separating church from state. Thats what happening in this country. Don't expect politeness, Nutbars.

Its time reasonable, logical thinking people stop having to tip toe through Christian's psychotic brand of bullshit.
Comment by Christy on September 18, 2008 at 9:55pm
I love SCIENCE! I love scientists! woo woo!

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