There was a fascinating show on BBC's Horizon program about the recent discovery of epigenetics. If you Google "epigenetics" you'll find plenty of material to peruse.

Biology stands on the brink of a shift in the understanding of inheritance. The discovery of epigenetics – hidden influences upon the genes – could affect every aspect of our lives.

At the heart of this new field is a simple but contentious idea – that genes have a 'memory'. That the lives of your grandparents – the air they breathed, the food they ate, even the things they saw – can directly affect you, decades later, despite your never experiencing these things yourself. And that what you do in your lifetime could in turn affect your grandchildren.

The conventional view is that DNA carries all our heritable information and that nothing an individual does in their lifetime will be biologically passed to their children. To many scientists, epigenetics amounts to a heresy, calling into question the accepted view of the DNA sequence – a cornerstone on which modern biology sits.

Epigenetics adds a whole new layer to genes beyond the DNA. It proposes a control system of 'switches' that turn genes on or off – and suggests that things people experience, like nutrition and stress, can control these switches and cause heritable effects in humans.

In a remote town in northern Sweden there is evidence for this radical idea. Lying in Överkalix's parish registries of births and deaths and its detailed harvest records is a secret that confounds traditional scientific thinking. Marcus Pembrey, a Professor of Clinical Genetics at the Institute of Child Health in London, in collaboration with Swedish researcher Lars Olov Bygren, has found evidence in these records of an environmental effect being passed down the generations. They have shown that a famine at critical times in the lives of the grandparents can affect the life expectancy of the grandchildren. This is the first evidence that an environmental effect can be inherited in humans.

In other independent groups around the world, the first hints that there is more to inheritance than just the genes are coming to light. The mechanism by which this extraordinary discovery can be explained is starting to be revealed.

Professor Wolf Reik, at the Babraham Institute in Cambridge, has spent years studying this hidden ghost world. He has found that merely manipulating mice embryos is enough to set off 'switches' that turn genes on or off.

For mothers like Stephanie Mullins, who had her first child by in vitro fertilisation, this has profound implications. It means it is possible that the IVF procedure caused her son Ciaran to be born with Beckwith-Wiedemann Syndrome – a rare disorder linked to abnormal gene expression. It has been shown that babies conceived by IVF have a three- to four-fold increased chance of developing this condition.

And Reik's work has gone further, showing that these switches themselves can be inherited. This means that a 'memory' of an event could be passed through generations. A simple environmental effect could switch genes on or off – and this change could be inherited.

His research has demonstrated that genes and the environment are not mutually exclusive but are inextricably intertwined, one affecting the other.

The idea that inheritance is not just about which genes you inherit but whether these are switched on or off is a whole new frontier in biology. It raises questions with huge implications, and means the search will be on to find what sort of environmental effects can affect these switches.

After the tragic events of September 11th 2001, Rachel Yehuda, a psychologist at the Mount Sinai School of Medicine in New York, studied the effects of stress on a group of women who were inside or near the World Trade Center and were pregnant at the time. Produced in conjunction with Jonathan Seckl, an Edinburgh doctor, her results suggest that stress effects can pass down generations. Meanwhile research at Washington State University points to toxic effects – like exposure to fungicides or pesticides – causing biological changes in rats that persist for at least four generations.

This work is at the forefront of a paradigm shift in scientific thinking. It will change the way the causes of disease are viewed, as well as the importance of lifestyles and family relationships. What people do no longer just affects themselves, but can determine the health of their children and grandchildren in decades to come. "We are," as Marcus Pembrey says, "all guardians of our genome."

There's also a video about epigenetics available from NOVA's ScienceNOW.

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If I recall correctly, the basics of epigenetics (that the environmental condition of the mother can affect the development of the embryo) is pretty well established. This looks to be simply extending the range of the effect, postulating that the environmental switches may not only influence the immediate development, but also determine what position said 'switches' are in during the reproductive period of the next generation. Interesting stuff.
I wonder what a religious person would make of all this?
Hi Elaine,

A religious person is most likely not going to think about it. :-)

Science is the devil's work. God told us all we need to know . . . thousands of years ago.
A Roman Catholic would accept this as a scientific theory that may be valid until proven false (cuz the Pope says that is sound theology). Most evangelical Christians (but not Francis Collins) would not believe it (or ignore it).
Its an interesting premise. Something similar I recall being mentioned in some scientists hypotheses on how 'instinct' comes about. Those little things that all species seem to know without being taught.

In the fiction/scifi area, this what the plot of the video game Assassin's Creed revolved around. They used a machine to immerse the main character in a virtual world that allowed him to recall 'memories' of events that happened to his ancestor, and were passed to him through DNA.

Back to reality; this seems a rather difficult thing to study (but that could be said every time science ventures down an unknown path). If you could get test subjects for it, the comparison I think might be most interesting, is to look at some of the differences between siblings born far apart. For example one born when the parents are in their early 20s, then the second born when the parents are in their 40s. If a significant event happened to the parents in-between that might even make the analysis better.
It makes perfect sense.
I mean, in an ultimately complex, confusing way.
Everything comes down to numbers. Everything comes down to environment and genetics.
And now featured!
fundamental Christians would have to believe that this is supported by scripture: [Exodus 20:5] "You shall not worship them or serve them; for I, the Lord your God, am a jealous God, visiting the iniquity of the fathers on the children, on the third and the fourth generations of those who hate Me,"
Hey, doubtingSteve,

How apropos! You really know your scripture. :-)

Here's some obscure scripture I bet you've overlooked . . .

My family moved to Guam when I was nine or so, and the place was crawling with jungle-sized crows. They made a terrible racket, but if you clapped your hands together (even lightly), they would scatter. Much flightier than any crows I had seen before in my life.

Apparently, that species of bird had overpopulated in the past and was responsible for getting the brown tree snake (unique to Guam) onto the endangered species list. The local government enacted some kind of reward system for killing the birds to promote population control, so guns were going off all over the island for several years until ecologists called it off.

My point being, that years and who knows how many generations of birds later, any noise even resembling the sound of a gun would scare these birds off, even though they had been born after the bird-genocide.
That was really intresting man and one of the reasons I love this site, however I want to ask can anybody tell me what that could mean to my kids.

Is it more likely after these findings that my kids will be prone to mental health problems ? I have to add that my da was an alcoholic, his dad was, as was his. I stopped drinking 14 years ago due to behavioral issues (ol) and I have a long histroy of mental health problems.

My question, do my kids, my grandchildren and others down the line now fucked due to me.


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