So, here's an interesting thought.
Let's say that you were to find significant evidence that the reality that you perceive is nothing more than a product of your imagination. This evidence, while overwhelming, would not fully convince you. However, you'd know that in order to find out, you'd have to fully accept the truth, which is the one that what you've experienced so far isn't the absolute reality, and everyone you've ever thought you've known has been nothing more than some electrical reactions in your almost disabled brain. Now, if you accepted this, and the evidence turned out to be correct, this world would disappear and you would wake up in the real world, where your family might be waiting for you. Everyone you'd ever known, anyone you'd ever heard about, the physical laws, every philosopher, every book, every cookie recipe would seize to exist.
Would you take the chance to leave everything you've ever known, even though you knew it wasn't real, to enter the world that all the evidence pointed to?